**Role Summary**



The Gene Therapy/Hemophilia portfolio has an exciting pipeline with 4 potential launches within the next 3 years. This includes a new transformative and breakthrough Gene therapy (GTx) for Duchenne Muscular Dystrophy (DMD) as well as 3 transformative, breakthrough hemophilia agents - Hemophilia A GTx, Hemophilia B GTx, and a subcutaneously delivered monoclonal antibody to treat hemophilia A & B (marstacimab). All these products represent significant therapeutic benefits to patients offering breakthrough innovations that address today's high burden of treatment.



Marstacimab, a human monoclonal immunoglobulin G isotype that promotes clotting activity by targeting an endogenous anticoagulant protein called tissue factor pathway inhibitor (TFPI), provides a Novel Non-Factor (NNF) approach to improve blood coagulation for patients with either Hemophilia A or Hemophilia B. Marstacimab is projected to be the amongst the first subcutaneous therapies to launch in Hemophilia B. The product is currently in Phase 3 with an expected launch in mid-2024 with blockbuster potential and is one of the 25x25 breakthrough assets within PBG.



It will be essential to co-position Marstacimab with our Hemophilia GTx programs with careful consideration of our in-line products. Preparing for successful launch while ensuring lock-step alignment with the GTx launches and in-line product strategies will be critical to success.



The global Hemophilia community encompass a complex set of stakeholders, engaged end-to-end, from discovery through policy shaping for patient access. Given the transformative nature of our programs and the very competitive nature of the hemophilia marketplace, we need to prepare both the internal Pfizer and external Hemophilia community for great change. Therefore, we must build our capabilities accordingly. Key strategic pillars for ensuring a successful launch are:



+ **Develop the Market:** Position Marstacimab vis a vis Pfizer's portfolio (pipeline (GTx) and in-line)

+ **Establish A New Treatment of Choice:** Elucidate the unmet need and build confidence in the anti-TFPI mechanism and execute the global differentiation strategy for Marstacimab

+ **Ensure Seamless Access & Early Uptake:** Obtain high quality access by assuring long term value

+ **Elevate Patient & Customer Experience:** Develop seamless patient services



The Launch Operations and Excellence Lead is a critical role reporting to the Marstacimab Brand lead and responsible for ensuring the overall operational/commercial readiness for the program. The Lead (She/he) will be responsible for:



+ Launch planning coordination and tracking, inclusive of project management of the detailed launch plan identification of cross-functional interdependencies, escalation of critical issues impacting organizational readiness and pressure testing key launch assumptions against plan.

+ Determining and tracking all launch readiness milestones. A proactive, "lean-in" approach is required in order hold the launch team responsible for executing the launch plan, identification of potential risks and/or issues and working with launch team to identify a mitigation plan for the issues.

+ Leading global launch sequencing for Marstacimab (in partnership with PHI)

+ Supporting the creation and execution of the launch stage-gates from the brand strategy map to the integrated launch plan (in partnership with the brand lead)

+ Supporting the OP process for Marstacimab, orchestrating OpEx requests across the global/XF/regional teams and allocation management



The successful candidate will have a demonstrated track record of complex project management in a fast-moving launch environment. Launch experience in implementation during a global product launch is highly desirable.



Collaboration evidenced through leadership at every level will be another attribute of the successful candidate. Demonstrated expertise and capabilities in matrix, cross-functional leadership, and influencing without authority will be attributes of the successful candidate; engagement in working with Sr. Executives across Businesses (e.g., Regional Presidents and Country Leads) and with cross-functional global and local line functions (e.g., Regulatory, Chief Business Office, Corporate Affairs) is highly preferred.



**Roles and Responsibilities**



**Operational Responsibilities**



+ Lead and manage operational launch plan development with key stakeholders both internal (all functions that contribute to the launch readiness within Pfizer) and external (i.e. agencies supporting launch). Ensure launch ops plan alignment with Brand Strategy Map (BSM) framework.

+ Ensure on time launch and execution of key milestones via the development of a detailed, tangible, and actionable plan - hold teams accountable for deliverables and attainment of key milestones

+ Develop and manage holistic launch readiness updates for the Hem pipeline to the GLT and senior leadership. Optimize process to provide launch status updates, increase launch progress transparency, and escalate issues as needed to maintain progress.

+ Develop strategic and operational KPIs, establish baselines, measure KPI progress and communicate progress GLT and senior leadership

+ Owner of launch operational capabilities (e.g., DLPP, LEAP, GLocal portal) for Marstacimab

+ Support alignment between global and local markets, and ensure aligned launch readiness reports and dashboards

+ In partnership with Commercial Leads, lead GLocal launch readiness meetings, leadership of GLT launch operations (i.e., agenda coordination, etc.) and follow up on key workstreams and deliverables

+ Partner with marstacimab Commercial Lead to form marstacimab GLocal launch team

+ Lead iterative launch sequencing efforts and scenario planning for Marstacimab in partnership with Commercial Leads, PHI, Regulatory and PGS

+ Act as a cross-functional leader by integrating execution plans across all Pfizer functions to drive innovative ideas that can support a successful launch



**Launch Excellence Responsibilities**



+ Gather and maintain lessons learned from launch team and liaise with Launch Navigation Group to share learnings and grow overall Pfizer Launch Excellence (better, faster, smarter). Active participation in Launch Navigation Group community meetings.

+ Co-create and champion relevant Collective Advantage activities. Participate in Launch Excellence workshops and knowledge sharing events as necessary.

+ Have a clear understanding of the Launch Navigation Group priorities, the type of resources and expertise available, and how to actively engage with the network to pull these resources into the team

+ Lead implementation of new LNG operational frameworks, tools and/or resources for the Hem pipeline

+ Excellence - ensure the correct measures of success are established and tracked at all phases of the launch cycle



**Qualifications**



+ The candidate must be a self-starter who is able to focus AND multitask in a fast-paced and dynamic environment and support the team through key strategic decisions for Pfizer's rare disease portfolio as well as able to understand the operational complexities required to execute against GLocal Launch Readiness for a breakthrough medicine in a mature hemophilia market.

+ He/she must be mature, self-driven, have exceptional learning agility and a high degree of comfort with ambiguity.

+ 7-10+ years of pharmaceutical industry experience in marketing, strategy, new product launch, business development in pharmaceutical, medical device or biotechnology companies.

+ Demonstrated launch experience and experience in managing global launches

+ Strong experience in and passion for global launch operations

+ High performing project leadership skills

+ Visionary leader, proven track record of delivering on target goals

+ BA/BS - degree required.

+ Candidate demonstrates a breadth of diverse leadership experiences and capabilities including: the ability to influence and collaborate with peers, oversee, and guide the work of cross functional teams to achieve meaningful outcomes and create business impact.



**Other Job Details:**



+ **Last day to apply:** **October** **4** **, 2022**

+ Work Location Assignment:Flexible

+ Eligible for employee referral bonus



\#LI-PFE #LI-REMOTE



Relocation assistance may be available based on business needs and/or eligibility.



**Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.**



**Sunshine Act**



Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.



**EEO & Employment Eligibility**



Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.



Marketing and Market Research



\#LI-PFE