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Job Description
About the role:
The Cell Engager team of the Oncology DDU is looking for an Associate Scientist/Scientist 1 with demonstrated in vivo/ex vivo skills in immuno-oncology drug discovery or translational sciences. You will be involved in discovery and development of novel therapeutics in the cell engager space, supporting new and ongoing pipeline programs using the COBRA and next generation immune engagers platform.
This is a lab-based role. As an important member of the team, you will be responsible for new in vivo model development, target validation, assessing next-generation COBRA/immune cell engager concepts and advancing novel research molecules towards development candidates and IND. You will collaborate with important partners in the ODDU (IOI, C2H) GB, DSRE, DMPK, Translational teams and CTI.
How you will contribute:
Development and characterization of animal models to test the biological efficacy of therapeutic agents for oncology indications.
Design in vivo efficacy models in xenograft and PDX models, ex vivo functional assays to assess therapeutic concepts aligned with principles of the COBRA platform
Lead or help with imaging studies to evaluate efficacy, biodistribution and mechanistic readouts using imaging modalities like PET/CT/IVIS platforms.
Participate in analysis of in vivo studies to help establish PK/PD/efficacy relationships.
Use immune readouts such FACS based immunophenotyping, cytokine profiling that can aid with both preclinical model selection and lead molecule screening.
Familiar and help with ex vivo tissue profiling and sample collections for IHC, Nanostring analysis.
Help with external collaborations with CROs and establish new protocols
Execute experiments and deliver comprehensive high quality data sets to help decision-making
Identify state-of-the-art experimental protocols and IO in vivo models
Identify, plans, and executes well defined scientific projects and communicate program strategy and timelines to management.
Present comprehensive technical or project reports and formal presentations
Be an in vivo lead on projects providing important scientific feedback to improve programs in a matrixed environment.
Collaborate with others across sites and act as liaison for in vitro pharmacology and GB teams.
Participate in and manage external interactions and collaborations with companies and academic research groups and potential collaborator
Minimum Requirements/Qualifications:
Scientist 1: PhD in Immunology, Cell Biology or Biochemistry, or MS with 6+ years experience (industry experience preferred), or BS +8 years in Immunology, Cell Biology, Pharmacology.
Associate Scientist: BS with at least 5 years of research experience or MS with at least 3 years of research in a lab setting working with animals
Proficiency with in vivo efficacy rodent models, including mouse syngeneic, xenograft and PDX models
Experimental skills, including mammalian tissue culture, in vivo model development, drug administration by multiple routes (IV, SQ, IP, IT, PO), and blood/tissue collection.
Experience culturing and maintaining human tumor cell lines and primary human cells, preferably T cells and Macrophages, with best practices in tissue culture is important.
Experience with ex vivo tumoroid/organoid cultures nice to have.
Small animal In vivo imaging experience preferred across IVIS, PET/CT imaging modalities. Imaging data analysis knowledge across platforms
Knowledge in immunology or immune oncology. Understanding of cell engagers and cell therapies.
Experience with biologics (Antibodies, ADCs, Cell therapies etc.)
Knowledge of protein biochemistry and experience conjugating the proteins with Fluorescent and radiolabeled probes.
Hands -on basic experience with multi-color flow cytometry, molecular biology techniques (PCR, Gibson assembly, cloning etc), ELISA, MSD and other standard cell based, and non-cell based biochemical assays.
Experience in molecular biology and biochemical techniques such as western blot, molecular cloning.
Use of scientific databases and application for data management and data analysis (Graph Pad Prism, Soft Max Pro, Office 365, FlowJo etc).
What Takeda can offer you:
Comprehensive Healthcare: Medical, Dental, and Vision
Financial Planning & Stability: 401(k) with company match and Annual Retirement Contribution Plan
Health & Wellness programs including onsite flu shots and health screenings
Generous time off for vacation and the option to purchase additional vacation days
Community Outreach Programs and company match of charitable contributions
Family Planning Support
Flexible Work Paths
Tuition reimbursement
More about us:
At Takeda, we are transforming patient care through the development of novel specialty pharmaceuticals and best in class patient support programs. Takeda is a patient-focused company that will inspire and empower you to grow through life-changing work.
Certified as a Global Top Employer, Takeda offers stimulating careers, encourages innovation, and strives for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.
In accordance with the CO Equal Pay Act, Colorado Applicants Are Not Permitted to Apply.
EEO Statement
Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.
Locations
Boston, MA
Worker Type
Employee
Worker Sub-Type
Regular
Time Type
Full time
